PFA Manual Diaphragm Valve (Clamp Connections)
The CYLEX PFA Manual Diaphragm Valve with Clamp Connections is engineered for ultimate reliability in handling ultra-pure and highly aggressive fluids. Crafted from transparent PFA material, it ensures zero contamination, maximum chemical resistance, and easy visual flow monitoring. The diaphragm isolation design completely separates the fluid path from the operating mechanism, guaranteeing a leak-proof seal. Featuring standard clamp connections (SEMI Flanges) for quick and secure installation, this valve is the preferred choice for critical applications in semiconductor, biotechnology, and chemical processing industries.
Model: D-F-MDV2-G104-01A4-FA
Body Size: 25mm
Connector: Flare
Port Size: 1/4″
Actuator Options: Open/Close Only
Control Port Direction: Same as fluid flow
Mounting Method: Threaded Flange
Body Material: Ultra-pure PFA
CYLEX supports small-batch customization, offers discounts for large quantities, fast delivery, and provides guaranteed after-sales service.
Get a quote or inquire for more information about custom processing of PFA Valves .
Processing Cycle:
Material:
Diaphragm: PTFE
Valve body: PFA
Categories :
CYLEXPRO PFA Manual Diaphragm Valve (Tri-Clamp Connection) – A Reliable Guarantee for Ultra-High Purity Fluid Processing
Key Features and Benefits:
● Ultra-High Purity and Excellent Chemical Resistance: The valve body is made of 100% high-purity PFA (perfluoroalkoxy resin), resistant to virtually all strong acids, bases, organic solvents, and ultrapure water, ensuring fluids are free of metal ion contamination.
● Zero Deadband and Visible Flow Path: The smooth, straight-through or weir-type flow path design ensures no media residue and is easy to clean and sterilize (CIP/SIP). The translucent valve body allows direct observation of the internal fluid and valve status.
● Absolutely Reliable Sealing: The unique diaphragm design completely isolates the valve stem, actuator, and other components from the process media, virtually eliminating the risk of external leakage and protecting moving parts from corrosive media.
● Quick and Hygienic Tri-Clamp Connection: Installation and removal are quick and easy, significantly reducing maintenance time and costs.
● Durable and Easy to Operate: The user-friendly manual design makes operation easy. The diaphragm is the only wearing part, making replacement simple, effectively extending the valve’s overall lifespan and reducing total cost of ownership.
Technical Specifications (D-F-MDV2-G104-01A4-FA):
| Use fluid | Pure water, chemical liquid | ||||||||||
| Fluid temperature | 5~120 °C (Note 1, Note 2) | ||||||||||
| Pressure resistance | 1.0 Mpa | ||||||||||
| Use pressure | A→B: 0~0.5 Mpa B→A: 0~0.5 Mpa | ||||||||||
| Valve seat leakage | 0 cm³/min (Water pressure) | ||||||||||
| Backpressure | 0~0.5Mpa | ||||||||||
| Ambient temperature | 0~60 ℃(With sensor 0〜50 ℃) | ||||||||||
| Diameter | Φ4 Φ6 Φ7 | ||||||||||
| Material | Diaphragm: PTFE Valve body: PFA | ||||||||||
Note 1: Please use hydrofluoric acid or chemical liquids containing hydrofluoric acid within the range of 5 to 80°C. | |||||||||||

Typical Applications:
● Semiconductor Industry: Ultrapure Water (UPW), Chemical Transfer (hydrofluoric acid, sulfuric acid, developer, etc.), CMP Slurry.
● Biopharmaceutical Industry: Water for Injection (WFI), buffers, culture media, cell culture, and filtration systems.
● Fine Chemicals: Transfer of high-purity chemical reagents and corrosive media.
● Laboratory and Analytical Instruments.
Why Choose CYLEXPRO?
At CYLEXPRO, we specialize in the design and manufacture of high-performance plastic valves. Each valve undergoes rigorous quality control to ensure reliable operation in the most demanding environments. We provide professional technical support and customized services to meet your specific needs.
Need a Quote or Custom Size? ✉️ Contact CYLEX Today!

Test Type Test Conditions Acceptance Criteria Test Results Burst pressure Hydraulic oil pressure builds up until a leak is detected The burst pressure must be greater than 2 times the rated pressure PASS Pressure envelope 414kPa (60psig)@180°C and 310kPa (45psig)@200°C thermal oil 1 million cycles at 1.5 times rated pressure without external leakage PASS No external leakage Drive cycle test 276kPa (40psig)@180°C and 207kPa (30psig)@200°C thermal oil cycle 500,000 times Functional performance up to 500K cycles without leakage in normally open valves PASS No external or port-to-port leakage <0.050 cc H₂O/hr 276 kPa (40 psig)@180°C and 207 kPa (30 psig)@200°C thermal oil 1 million cycles Functional performance up to 1 million cycles without leakage in normally closed valves PASS No external or port-to-port leakage <0.050 cc H₂O/hr Test Type Test Conditions Acceptance Criteria External medium leakage 552kPa (80psig) CDA Through 1/32″ ID tubing immersed in DI water, no bubbles per minute Port to Port Valve Testing 552kPa (80psig) CDA to valve outlet Less than 4 bubbles per minute through 1/32″ ID tubing immersed in DI water Valve drive Pressure decay 552kPa (80psig) CDA Pressure drop less than 7 kPa (1 psig/min)
Naming Convention

Pneumatic PFA Diaphragm Valve Model Indication and Model Selection

Surface Roughness Specifications & Surface Extractability Specifications

Surface roughness

Surface roughness specification
Surface roughness specification Component Description SEMI F57 0622 Recommended value Ra (µm) Typical test results Ra (µm) Injection molded valve body ≤0.35 ≤0.30 Machine-machined PTFE diaphragm ≤0.35 ≤0.20 Injection molded fitting flow path ≤0.35 ≤0.25 Machine-machined PFA valve body ≤0.60 ≤0.30 Machine-machined PTFE valve body ≤0.60 ≤0.40 Surface extractable specifications
The test liquid used was ultrapure water and the test was carried out at 85°C. The parts were leached after the prescribed rinsing pretreatment. The immersion time was 7 days.
Extractable ionic contamination

Surface extractable ionic contamination
Surface extractable ionic contamination Ion types SEMI F57 0622 Recommended value (µg/m³) Typical product measurement values (ultrapure water 85°C+5°C, 7-day leaching value) (µg/m³) Ammonium ions NH4+ ≤100 <0.1 Bromide ions Br− ≤100 <0.1 Chloride ions Cl− ≤100 <3 Fluoride ions F− ≤20000 <133 Nitrate ions NO3 ≤100 <0.1 Nitrite ions NO2 ≤100 <0.1 Phosphate ions PO42− ≤100 <0.1 Sulfate ions SO42− ≤100 <0.1 Extractable Metal Contamination

Surface extractable metal contaminants
Surface extractable metal contaminants Test items (tcp-ms) SEMI F57 0622 Recommended value (μg/m²) Typical product measurement values (ultrapure water 85°C + 5°C, 7-day leaching value) (μg/m²) Aluminum AI ≤5 <0.2 Arsenic AS ≤2 <0.1 Antimony Sb ≤2 <0.1 Barium Ba ≤15 <0.2 Boron B3 ≤30 <0.5 Cadmium Cd ≤2 <0.01 Calcium Ca ≤10 <0.21 Chromium Cr ≤1 <0.2 Copper Cu ≤10 <0.2 Iron Fe ≤5 <0.2 Lead Pb ≤1 <0.05 Lithium Li ≤2 <0.2 Magnesium Mg ≤2 <0.2 Manganese Mn ≤5 <0.2 Nickel Ni ≤1 <0.2 Potassium K ≤10 <0.5 Sodium Na ≤10 <0.5 Strontium Sr ≤0.5 <0.05 Titanium Ti ≤2 <0.1 Tin Sn ≤2 <0.1 Vanadium V ≤2 <0.01 Zinc Zn ≤5 <0.2
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